Mass Spectrometry Testing Services: Navigating the Spectrum of Analytical Science

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Mass spectrometry assays provide sensitive clinical and nonclinical bioanalytical data, making it the primary choice of technique in quantitating biomolecules and drug products. Mass spectrometry testing services have decades of experience and expertise with access to advanced equipment for delivering rapid, accurate, and reliable mass spectrometry analysis for biologics, pharmaceutical, and industrial applications. The current article explores mass spectrometry testing services for a wide spectrum of analytical science applications. 

Mass spectrometry testing services

Mass spectrometry combined with liquid or gas chromatography is commonly employed to detect analytes and study matrices. Quantitative LC-MS bioanalysis and LC-MS/MS services are often preferred for detecting analytes in different domains, including industrial, pharmaceutical, and agrochemical products. By delivering rapid and accurate detection, LC-MS analysis supports critical experiments that help make better decisions and accelerate drug development timelines while supporting supplementary research studies such as qPCR services

Mass spectrometry testing services have years of technical experience in troubleshooting challenges encountered during LC-MS method development and LC-MS method validation across different phases of drug development. LC-MS drug testing includes products such as biotherapeutics, proteins, peptides, small molecules, monoclonal antibodies, biomarkers, fusion proteins, and oligonucleotides. 

From a simple dilute-and-shoot approach to more advanced sample preparation techniques, bioanalytical laboratories can help drug developers select an ideal technique to meet project goals. They employ a strategic approach to improve method development specifications, provide excellent results, and increase analytical speed while complying with regulatory standards. These service providers are attentive to assay sensitivity, sample complexity, assay duration, increased productivity, and, when possible, automated systems for analyzing large numbers of study samples.

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Developing robust chromatography is crucial for successful quantitative mass spectrometry analysis. The primary aim of chromatography is to separate analytes from endogenous compounds and drug metabolites. Co-elution of metabolites or endogenous components results in ion enhancement or ion suppression, both of which may be detrimental to the bioanalytical assay. 

Identifying ideal mass spectrometry assay conditions requires knowledge of resolution, retention parameters, gradient slopes, and retention profiles of metabolites. This information, combined with data from in vitro and in vivo experiments, lays the foundation for informed decisions and robust drug development. 

Reliable mass spectrometry testing services deliver speed, cost-effectiveness, and high-quality results to support drug discovery and development projects for both large and small molecule drugs with a wide range of sample preparation techniques, analytical platforms, and high throughput analysis. Optimizing assay conditions for mass spectrometry testing needs evaluating MS response and developing a multiple reaction monitoring methodology. Hence, mass spectrometry testing services focus on acquiring data such as assessing whether target compounds require chemical modification before detection, identifying the best ionization mode for compound detection, estimating the ideal polarity for the best response, etc. 

LC-MS bioanalysis and other mass spectrometry-based approaches are challenging and include an iterative approach to attain optimal assay conditions that maximize assay sensitivity and specificity. These specific requirements need a reliable expert to deliver robust analysis. Hence, drug developers often reach out to mass spectrometry testing services for developing rapid, reliable, accurate, and fit-for-purpose MS-based assays using state-of-the-art technology and scientific activities to provide superior drug development support and solutions. 

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